
Wellbutrin (also known by the generic term bupropion) is a highly in-demand prescription medication prescribed to help alleviate depression, seasonal affective disorder (SAD), and even smoking addiction in some instances. As great as it has been to the majority, Wellbutrin withdrawal symptoms will be experienced if the medication is all of a sudden stopped—especially cold turkey.
If you or a family member are considering tapering off Wellbutrin, below are some things to consider regarding what the withdrawal will be like, why we experience withdrawal, and how to safely taper off.

Why Do We Get Wellbutrin Withdrawal?
In contrast to narcotics or benzodiazepines, Wellbutrin is not addictive in the traditional sense. It does interfere with the balance of the significant neurotransmitters in your brain—dopamine and norepinephrine. When you stop the drug, your brain has to learn to do without it. The period during which your brain adjusts can cause a range of physical and emotional symptoms, referred to as discontinuation or withdrawal effects.
Common Wellbutrin Withdrawal Symptoms
Withdrawal symptoms may vary depending on the dose, how long you have been on the medication, and your body chemistry. Some people barely feel any discomfort, while others experience a tough time readjusting.
The most common symptoms that tend to be experienced are:
1. Mood swings and irritability
Most people are more sensitive emotionally or have mood swings unexpectedly when they withdraw from Wellbutrin. You may be cranky, or depression thoughts may return if the medication was initially prescribed for depression.
2. Fatigue and loss of energy
Wellbutrin is an energizing medication, therefore withdrawal from your system may leave you tired, with fatigue, or sluggish.
3. Sleep disturbances
Insomnia, strange dreams, or abnormal sleeping patterns are the norm for withdrawal. Other people are drowsy but still can’t sleep.
4. Headaches and dizziness
These are typically found within the first few days of withdrawal. You also get dizzy or somewhat fuzzy.
5. Flu-like symptoms
Although not everyone will experience this, other people seem to have the flu with aches, chills, and generally a bad feeling.
6. Stomach discomfort
Nausea, stomach upset, or loss of appetite can occur during withdrawal, particularly within the first few days.
7. Anxieties or restlessness
Restlessness, anxiety, or panic attacks can occur in some individuals, particularly if Wellbutrin was prescribed for depression or anxiety.
How Long Do Withdrawal Symptoms Last?
Length of withdrawal depends upon some factors:
- Dosage (more concentrated might take longer)
- Duration of drug use
- Taper schedule
- Subject sensitivity
Generally, withdrawal symptoms will begin a few days after stopping and will last 1 to 3 weeks, but the worst week is usually the first.
With all of that being said, there are a few people who will experience some lingering psychological symptoms (e.g., depression or anxiety) for a longer duration—especially if the medication had been abruptly discontinued without some other type of treatment program.
Safe Wellbutrin Withdrawal Tips
1. Never quit cold turkey (unless medically indicated)
Coming off Wellbutrin “cold turkey” will make withdrawal symptoms worse. Always ask your prescribing doctor before quitting. The safest way is to taper slowly.
2. Monitor your symptoms
Writing down your mood or journaling daily might help you notice trends, visualize the progress, and give your doctor valuable feedback.
3. Support your body
Drink water, healthy food, and a little bit of gentle exercise—maybe even a walk would trigger endorphins and balance mood.
4. Use support systems
Whatever, a friend, therapist, or support group, having someone to speak with can assist in making sense out of what is occurring. You’re not on your own.
5. Develop a contingency plan
Discuss other treatments or coping strategies with your doctor. They may attempt a different drug, therapy, or lifestyle change to manage their mental health.
When to seek help?
If you are considering dying seriously, have severe emotional upset, or have extreme physical problems, contact your doctor or mental health provider at once. Withdrawal will be unpleasant, but if done correctly, it should be a safe process.
The following are some signs that may require immediate help:
- Self-injurious thoughts
- Extreme depression or panic
- Paranoid behavior or hallucinations
- Palpitations or chest pain
Coming off any medication is a personal journey. What works for one person might not work for another. If you’re experiencing Wellbutrin withdrawal symptoms, remember: your discomfort is temporary, and there is support available.
With adequate preparation, time, and surveillance, the majority of people can taper safely off of Wellbutrin and re-stabilize. Always remain in close communication with your doctor, and never hesitate to inquire or request help.
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